InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCA12

Summary

InnateDB Gene

IDBG-80130.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA12

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 12

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000144452

Encoded Proteins

IDBP-80132

ATP-binding cassette, sub-family A (ABC1), member 12

IDBP-80140

ATP-binding cassette, sub-family A (ABC1), member 12

IDBP-388759

ATP-binding cassette, sub-family A (ABC1), member 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:214931542-215138428

Strand

Reverse strand

Band

q35

Transcripts

ENST00000272895	ENSP00000272895
ENST00000389661	ENSP00000374312
ENST00000412081	ENSP00000400231

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0034040	lipid-transporting ATPase activity
GO:0034191	apolipoprotein A-I receptor binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006869	lipid transport
GO:0010875	positive regulation of cholesterol efflux
GO:0019725	cellular homeostasis
GO:0030216	keratinocyte differentiation
GO:0031424	keratinization
GO:0032940	secretion by cell
GO:0033700	phospholipid efflux
GO:0035627	ceramide transport
GO:0043129	surfactant homeostasis
GO:0045055	regulated secretory pathway
GO:0048286	lung alveolus development
GO:0055088	lipid homeostasis
GO:0061436	establishment of skin barrier
GO:0072659	protein localization to plasma membrane
GO:2000010	positive regulation of protein localization to cell surface

Cellular Component

GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0097209	epidermal lamellar body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000050296

View Gene Order

ENSBTAG00000003472

Not yet available

Pathways

NETPATH

REACTOME

REACT_111158

ABCA transporters in lipid homeostasis pathway

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.134585

RefSeq

NM_015657 NM_173076

HUGO

OMIM

CCDS

CCDS33372 CCDS33373

HPRD

07416

IMGT

EMBL

GenPept

RNA Seq Atlas