InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABCA12

Summary

InnateDB Gene

IDBG-643637.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA12

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003472

Encoded Proteins

IDBP-696216

ATP-binding cassette, sub-family A (ABC1), member 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144452:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:103520024-103720887

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004518

ENSBTAP00000004518

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005102	receptor binding
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0034191	apolipoprotein A-I receptor binding

Biological Process

GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0010875	positive regulation of cholesterol efflux
GO:0030216	keratinocyte differentiation
GO:0031424	keratinization
GO:0032940	secretion by cell
GO:0033700	phospholipid efflux
GO:0035627	ceramide transport
GO:0043129	surfactant homeostasis
GO:0045055	regulated secretory pathway
GO:0048286	lung alveolus development
GO:0055088	lipid homeostasis
GO:0061436	establishment of skin barrier
GO:0072659	protein localization to plasma membrane
GO:2000010	positive regulation of protein localization to cell surface

Cellular Component

GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0097209	epidermal lamellar body

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000144452

View Gene Order

ENSMUSG00000050296

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_111158

ABCA transporters in lipid homeostasis pathway

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

mmu02010

ABC transporters pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

G5E556

UniProt Splice Variant

Entrez Gene

523479

UniGene

Bt.60068

RefSeq

NM_001191294

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02005862 DAAA02005863 DAAA02005864

GenPept

RNA Seq Atlas

523479