Version 5.4
Homo sapiens Gene: NXF3
Summary
InnateDB Gene IDBG-80369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NXF3
Gene Name nuclear RNA export factor 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147206
Encoded Proteins
IDBP-240299
nuclear RNA export factor 3
IDBP-378258
nuclear RNA export factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:103075810-103093125
Strand Reverse strand
Band q22.1
Transcripts
ENST00000395065 ENSP00000378504
ENST00000427570 ENSP00000404017
ENST00000497850
ENST00000468528
ENST00000470724
ENST00000494300
ENST00000460791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0006406 mRNA export from nucleus
GO:0006810 transport
GO:0016973 poly(A)+ mRNA export from nucleus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0042272 nuclear RNA export factor complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000057000
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9H4D5
TrEMBL
UniProt Splice Variant
Entrez Gene 56000
UniGene Hs.60386
RefSeq NM_022052
HUGO HGNC:8073
OMIM 300316
CCDS CCDS14503
HPRD
IMGT
EMBL AF346619 AJ277527 AJ277660 BC031616 CH471190 Z75746
GenPept AAH31616 AAL07564 CAC16589 CAC20434 CAI41984 EAW54722
RNA Seq Atlas 56000

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca