InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCR1

Summary

InnateDB Gene

IDBG-80821.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR1

Gene Name

chemokine (C-X-C motif) receptor 1

Synonyms

C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA

Species

Homo sapiens

Ensembl Gene

ENSG00000163464

Encoded Proteins

IDBP-80823

chemokine (C-X-C motif) receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26950764

CXCR1 regulates anti-Pseudomonas neutrophil responses through modulation of reactive oxygen species and interference with TLR5 expression.

Entrez Gene

Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:218162845-218166995

Strand

Reverse strand

Band

q35

Transcripts

ENST00000295683

ENSP00000295683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004918	interleukin-8 receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0019959	interleukin-8 binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0031623	receptor internalization
GO:0038112	interleukin-8-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa05120

Epithelial cell signaling in Helicobacter pylori infection pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04144

Endocytosis pathway

hsa04062

Chemokine signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

INOH website

GPCR signaling pathway

PID NCI

il8cxcr1_pathway

IL8- and CXCR1-mediated signaling events

Cross-References

SwissProt

P25024

TrEMBL

UniProt Splice Variant

Entrez Gene

3577

UniGene

Hs.194778

RefSeq

NM_000634

HUGO

HGNC:6026

OMIM

146929

CCDS

CCDS2409

HPRD

IMGT

EMBL

AB032728 AB032729 AB032730 AB032731 AB032732 AC097483 AK312668 AY651785 AY916762 AY916763 AY916764 AY916765 AY916766 AY916769 AY916772 AY916773 BC028221 BC072397 CH471063 CR541994 CR542029 L19591 L19592 M68932 U11870 X65858

GenPept

AAA59159 AAA59160 AAA64378 AAB59436 AAH28221 AAH72397 AAT46689 AAX93212 AAY21512 AAY21513 AAY21514 AAY21515 AAY21516 AAY21519 AAY21522 AAY21523 BAA92290 BAA92291 BAA92292 BAA92293 BAA92294 BAG35550 CAA46688 CAG46791 CAG46826 EAW70590

RNA Seq Atlas

3577