InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCR1

Summary

InnateDB Protein

IDBP-80823.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR1

Protein Name

chemokine (C-X-C motif) receptor 1

Synonyms

C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA;

Species

Homo sapiens

Ensembl Protein

ENSP00000295683

InnateDB Gene

IDBG-80821 (CXCR1)

Protein Structure

UniProt Annotation

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004918	interleukin-8 receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0019959	interleukin-8 binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0031623	receptor internalization
GO:0038112	interleukin-8-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000174 CXC chemokine receptor 1/2
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR001355 CXC chemokine receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00427
PR00237
PR00657
PR00645
PR00572

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25024