Version 5.4
Homo sapiens Gene: RTN1
Summary
InnateDB Gene IDBG-8086.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN1
Gene Name reticulon 1
Synonyms NSP
Species Homo sapiens
Ensembl Gene ENSG00000139970
Encoded Proteins
IDBP-8088
reticulon 1
IDBP-8090
reticulon 1
IDBP-240221
reticulon 1
IDBP-807181
reticulon 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:59595976-59870966
Strand Reverse strand
Band q23.1
Transcripts
ENST00000267484 ENSP00000267484
ENST00000342503 ENSP00000340716
ENST00000395090 ENSP00000378525
ENST00000432103
ENST00000481205
ENST00000474911
ENST00000490111
ENST00000557422
ENST00000611068 ENSP00000483039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030182 neuron differentiation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021087
View Gene Order
ENSBTAG00000011451
Not yet available
Cross-References
SwissProt
TrEMBL Q2L7A7 Q2NKQ5
UniProt Splice Variant
Entrez Gene 6252
UniGene
RefSeq NM_021136 NM_206852
HUGO HGNC:10467
OMIM 600865
CCDS CCDS9740 CCDS9741
HPRD
IMGT
EMBL BC111694 DQ355431
GenPept AAI11695 ABC71342
RNA Seq Atlas 6252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca