Version 5.4
Homo sapiens Protein: RTN1
Summary
InnateDB Protein IDBP-8088.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN1
Protein Name reticulon 1
Synonyms NSP;
Species Homo sapiens
Ensembl Protein ENSP00000267484
InnateDB Gene IDBG-8086 (RTN1)
Protein Structure
UniProt Annotation
Function May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
Subcellular Localization Endoplasmic reticulum membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation. {ECO:0000269PubMed:9560466}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030182 neuron differentiation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR003388 Reticulon
PFAM PF02453
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16799
PhosphoSite PhosphoSite-Q16799
TrEMBL Q2NKQ5
UniProt Splice Variant
Entrez Gene 6252
UniGene Hs.641611
RefSeq NP_066959
HUGO HGNC:10467
OMIM 600865
CCDS CCDS9740
HPRD 02921
IMGT
EMBL BC000314 BC003003 BC090862 BC111694 CH471061 DQ355431 L10333 L10334 L10335
GenPept AAA59950 AAA59951 AAA59952 AAH00314 AAH03003 AAH90862 AAI11695 ABC71342 EAW80762

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca