Version 5.4
Homo sapiens Gene: SERPINA7
Summary
InnateDB Gene IDBG-81094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA7
Gene Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
Synonyms TBG
Species Homo sapiens
Ensembl Gene ENSG00000123561
Encoded Proteins
IDBP-81096
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
IDBP-81098
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3\'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:106032442-106038738
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372563 ENSP00000361644
ENST00000327674 ENSP00000329374
ENST00000487487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0042562 hormone binding
Biological Process
GO:0007568 aging
GO:0009791 post-embryonic development
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0031667 response to nutrient levels
GO:0033189 response to vitamin A
GO:0034695 response to prostaglandin E
GO:0042493 response to drug
GO:0043434 response to peptide hormone
GO:0048545 response to steroid hormone
GO:0051412 response to corticosterone
GO:0070327 thyroid hormone transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031271
View Gene Order
ENSBTAG00000047655
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.76838
RefSeq NM_000354
HUGO
OMIM
CCDS CCDS14518
HPRD 02438
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca