InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLA-DQA1

Summary

InnateDB Gene

IDBG-81099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DQA1

Gene Name

major histocompatibility complex, class II, DQ alpha 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000196735

Encoded Proteins

IDBP-81101

major histocompatibility complex, class II, DQ alpha 1

IDBP-81103

major histocompatibility complex, class II, DQ alpha 1

IDBP-239711

major histocompatibility complex, class II, DQ alpha 1

IDBP-374540

major histocompatibility complex, class II, DQ alpha 1

IDBP-602602

major histocompatibility complex, class II, DQ alpha 1

IDBP-596582

major histocompatibility complex, class II, DQ alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21441935

[Mus musculus] H2-Aa is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.

Entrez Gene

Summary

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32628179-32647062

Strand

Forward strand

Band

p21.32

Transcripts

ENST00000343139	ENSP00000339398
ENST00000374949	ENSP00000364087
ENST00000395363	ENSP00000378767
ENST00000422863	ENSP00000405797
ENST00000496318	ENSP00000437302
ENST00000482745	ENSP00000436546
ENST00000460633

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032395	MHC class II receptor activity
GO:0042605	peptide antigen binding

Biological Process

GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0010008	endosome membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030658	transport vesicle membrane
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0042613	MHC class II protein complex
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000036594

View Gene Order

Pathways

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_12555

Downstream TCR signaling pathway

REACT_12623

Generation of second messenger molecules pathway

REACT_12596

Translocation of ZAP-70 to Immunological synapse pathway

REACT_12582

Phosphorylation of CD3 and TCR zeta chains pathway

REACT_25078

Interferon gamma signaling pathway

REACT_19324

PD-1 signaling pathway

REACT_19344

Costimulation by the CD28 family pathway

REACT_12526

TCR signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04612

Antigen processing and presentation pathway

hsa04940

Type I diabetes mellitus pathway

hsa05330

Allograft rejection pathway

hsa05320

Autoimmune thyroid disease pathway

hsa05322

Systemic lupus erythematosus pathway

hsa05332

Graft-versus-host disease pathway

hsa05310

Asthma pathway

hsa04672

Intestinal immune network for IgA production pathway

hsa05416

Viral myocarditis pathway

hsa05140

Leishmaniasis pathway

hsa05150

Staphylococcus aureus infection pathway

hsa05145

Toxoplasmosis pathway

hsa04145

Phagosome pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

E9PMV2 F6UB03 O19703 Q67A92 Q67A93 Q67AA5 Q67AA6 Q67AA7 Q67AB5 Q67AB6 Q67AB7 Q67AB8 Q67AB9 Q67AC0 Q67AC1 Q67AC2 Q67AC3 Q67AC4

UniProt Splice Variant

Entrez Gene

3117

UniGene

Hs.387679 Hs.625753 Hs.666607 Hs.676554 Hs.706240

RefSeq

NM_002122 XM_006715079

HUGO

HGNC:4942

OMIM

146880

CCDS

CCDS4752

HPRD

06765

IMGT

EMBL

AL662789 AY375955 AY375956 AY375957 AY375958 AY375959 AY375960 AY375961 AY375962 AY375963 AY375964 AY375972 AY375973 AY375974 AY375986 AY375987 M83887

GenPept

AAA59757 AAQ89959 AAQ89960 AAQ89961 AAQ89962 AAQ89963 AAQ89964 AAQ89965 AAQ89966 AAQ89967 AAQ89968 AAQ89976 AAQ89977 AAQ89978 AAQ89990 AAQ89991

RNA Seq Atlas

100509457 102723931 102724794 3117