InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT6

Summary

InnateDB Gene

IDBG-81171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT6

Gene Name

wingless-type MMTV integration site family, member 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115596

Encoded Proteins

IDBP-81173

wingless-type MMTV integration site family, member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97%% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:218859821-218874233

Strand

Forward strand

Band

q35

Transcripts

ENST00000233948	ENSP00000233948
ENST00000486233

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0007275	multicellular organismal development
GO:0009798	axis specification
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045165	cell fate commitment
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060684	epithelial-mesenchymal cell signaling
GO:0061303	cornea development in camera-type eye
GO:0070172	positive regulation of tooth mineralization
GO:0071300	cellular response to retinoic acid
GO:0072079	nephron tubule formation
GO:0072080	nephron tubule development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix