InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT6

Summary

InnateDB Protein

IDBP-81173.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT6

Protein Name

wingless-type MMTV integration site family, member 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000233948

InnateDB Gene

IDBG-81171 (WNT6)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. {ECO:0000269PubMed:22370641}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level). {ECO:0000269PubMed:22370641}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0007275	multicellular organismal development
GO:0009798	axis specification
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045165	cell fate commitment
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060684	epithelial-mesenchymal cell signaling
GO:0061303	cornea development in camera-type eye
GO:0070172	positive regulation of tooth mineralization
GO:0071300	cellular response to retinoic acid
GO:0072079	nephron tubule formation
GO:0072080	nephron tubule development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix