InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MOCS3

Summary

InnateDB Gene

IDBG-81183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOCS3

Gene Name

molybdenum cofactor synthesis 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000124217

Encoded Proteins

IDBP-81187

molybdenum cofactor synthesis 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:50958826-50963931

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000244051

ENSP00000244051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004792	thiosulfate sulfurtransferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity
GO:0016783	sulfurtransferase activity
GO:0042292	URM1 activating enzyme activity
GO:0046872	metal ion binding
GO:0061604	molybdopterin-synthase sulfurtransferase activity
GO:0061605	molybdopterin-synthase adenylyltransferase activity
GO:0070733	protein adenylyltransferase activity

Biological Process

GO:0002098	tRNA wobble uridine modification
GO:0002143	tRNA wobble position uridine thiolation
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006777	Mo-molybdopterin cofactor biosynthetic process
GO:0018117	protein adenylylation
GO:0018192	enzyme active site formation via L-cysteine persulfide
GO:0032324	molybdopterin cofactor biosynthetic process
GO:0032447	protein urmylation
GO:0034227	tRNA thio-modification
GO:0044281	small molecule metabolic process