InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PAPSS2

Summary

InnateDB Gene

IDBG-81304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPSS2

Gene Name

3'-phosphoadenosine 5'-phosphosulfate synthase 2

Synonyms

ATPSK2; BCYM4; SK2

Species

Homo sapiens

Ensembl Gene

ENSG00000198682

Encoded Proteins

IDBP-81308

3'-phosphoadenosine 5'-phosphosulfate synthase 2

IDBP-381892

3'-phosphoadenosine 5'-phosphosulfate synthase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3\'-phosphoadenosine 5\'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:87659613-87747705

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000361175	ENSP00000354436
ENST00000456849	ENSP00000406157
ENST00000465996
ENST00000482258

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004020	adenylylsulfate kinase activity
GO:0004781	sulfate adenylyltransferase (ATP) activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0000103	sulfate assimilation
GO:0001501	skeletal system development
GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0060348	bone development