InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAPSS2

Summary

InnateDB Protein

IDBP-381892.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPSS2

Protein Name

3'-phosphoadenosine 5'-phosphosulfate synthase 2

Synonyms

ATPSK2; BCYM4; SK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000406157

InnateDB Gene

IDBG-81304 (PAPSS2)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Spondyloepimetaphyseal dysplasia Pakistani type (SEMD-PA) [MIM:612847]: A bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Clinical features include short stature evidenced at birth, short and bowed lower limbs, mild brachydactyly, kyphoscoliosis, abnormal gait, enlarged knee joints. Some patients may manifest premature pubarche and hyperandrogenism associated with skeletal dysplasia and short stature. {ECO:0000269PubMed:19474428, ECO:0000269PubMed:9714015}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in cartilage and adrenal gland. {ECO:0000269PubMed:19474428}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004020	adenylylsulfate kinase activity
GO:0004781	sulfate adenylyltransferase (ATP) activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0000103	sulfate assimilation
GO:0001501	skeletal system development
GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0060348	bone development

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002650 Sulphate adenylyltransferase
IPR002891 Adenylylsulphate kinase
IPR015947 PUA-like domain
IPR024951 Sulphate adenylyltransferase catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01583
PF01747

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95340

PhosphoSite