InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GUCY2F

Summary

InnateDB Gene

IDBG-82165.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY2F

Gene Name

guanylate cyclase 2F, retinal

Synonyms

CYGF; GC-F; GUC2DL; GUC2F; RETGC-2; ROS-GC2

Species

Homo sapiens

Ensembl Gene

ENSG00000101890

Encoded Proteins

IDBP-82167

guanylate cyclase 2F, retinal

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:109372906-109482072

Strand

Reverse strand

Band

q23

Transcripts

ENST00000218006

ENSP00000218006

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016849	phosphorus-oxygen lyase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0009190	cyclic nucleotide biosynthetic process
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005640	nuclear outer membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0097381	photoreceptor disc membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042282

View Gene Order

ENSBTAG00000026003

Not yet available

Pathways

NETPATH

REACTOME

REACT_111102

Signal Transduction pathway

REACT_160102

Diseases associated with visual transduction pathway

REACT_160125

Visual phototransduction pathway

REACT_163722

The phototransduction cascade pathway

REACT_163919

Inactivation, recovery and regulation of the phototransduction cascade pathway

REACT_116125

Disease pathway

KEGG

hsa00230

Purine metabolism pathway

hsa04744

Phototransduction pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

cone_pathway

Visual signal transduction: Cones

rhodopsin_pathway

Visual signal transduction: Rods

Cross-References

SwissProt

P51841

TrEMBL

UniProt Splice Variant

Entrez Gene

2986

UniGene

Hs.123074

RefSeq

NM_001522

HUGO

HGNC:4691

OMIM

300041

CCDS

CCDS14545

HPRD

IMGT

EMBL

AL031387 L37378

GenPept

AAA74451 CAB41303

RNA Seq Atlas

2986