Version 5.4
Homo sapiens Gene: DOCK10
Summary
InnateDB Gene IDBG-82365.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK10
Gene Name dedicator of cytokinesis 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135905
Encoded Proteins
IDBP-82367
dedicator of cytokinesis 10
IDBP-292975
dedicator of cytokinesis 10
IDBP-389152
dedicator of cytokinesis 10
IDBP-389153
dedicator of cytokinesis 10
IDBP-389154
dedicator of cytokinesis 10
IDBP-585622
dedicator of cytokinesis 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:224765090-225042445
Strand Reverse strand
Band q36.2
Transcripts
ENST00000258390 ENSP00000258390
ENST00000409592 ENSP00000386694
ENST00000422684 ENSP00000395178
ENST00000435582 ENSP00000394552
ENST00000458608 ENSP00000397389
ENST00000492251
ENST00000489831
ENST00000472652
ENST00000492369
ENST00000471810
ENST00000474102
ENST00000535663 ENSP00000437947
ENST00000543715
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0030334 regulation of cell migration
GO:0032319 regulation of Rho GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038608
View Gene Order
ENSBTAG00000000581
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.46578 Hs.623875
RefSeq NM_001290263 NM_014689 XM_005246672 XM_005246673 XM_005246674
HUGO
OMIM
CCDS CCDS46528 CCDS74661
HPRD 10919
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca