InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOCK10

Summary

InnateDB Protein

IDBP-82367.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK10

Protein Name

dedicator of cytokinesis 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000258390

InnateDB Gene

IDBG-82365 (DOCK10)

Protein Structure

UniProt Annotation

Function

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells. {ECO:0000269PubMed:21514340, ECO:0000269PubMed:9734811}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0017048	Rho GTPase binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0030334	regulation of cell migration
GO:0032319	regulation of Rho GTPase activity

Cellular Component

GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001849 Pleckstrin homology domain
IPR010703 Dedicator of cytokinesis C-terminal
IPR016024 Armadillo-type fold
IPR021816 Dedicator of cytokinesis C/D, N-terminal

PFAM

PF00169
PF06920
PF11878

PRINTS

PIRSF

SMART

SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96BY6