Homo sapiens Gene: ZBP1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-82385.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | ZBP1 | ||||||||||||||||||||||
Gene Name | Z-DNA binding protein 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000124256 | ||||||||||||||||||||||
Encoded Proteins |
Z-DNA binding protein 1
Z-DNA binding protein 1
Z-DNA binding protein 1
Z-DNA binding protein 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
ZBP1 is a cytosolic DNA sensor that upon binding to DNA, associates with IRF3 transcription factor and TBK1 serine/threonine kinase, selectively enhancing DNA mediated induction of type-I-IFN.
ZBP1 is a cytosolic pattern recognition receptor of double-stranded DNA and is essential for IRF3 activation and interferon beta expression triggered by human cytomegalovirus (HCMV), as well as being sufficient to enhance HCMV-stimulated beta interferon transcription and secretion.
ZBP1 (DAI) enhanced HIV-1 replication, which is largely impaired by mutations at kappaB sites in HIV-1 long terminal repeat (LTR) or by suppressing activation of NF-kappaB.
ZBP1 interacts with RIPK3 to mediate virus-induced necrosis. (Demonstrated in mice)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] Zbp1 interacts with Ripk3 to mediate virus-induced necrosis.
[Mus musculus] Ddx58 acts in parallel with Zbp1 in an RNA polymerase III-dependent manner to initiate glial responses to herpes simplex virus-1.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 20:57603846-57620576 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q13.31 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
IRF3 mediated activation of type 1 IFN pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
STING mediated induction of host immune responses pathway
IRF3-mediated induction of type I IFN pathway
Innate Immune System pathway
Regulation of innate immune responses to cytosolic DNA pathway
Immune System pathway
Cytosolic sensors of pathogen-associated DNA pathway
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KEGG |
Cytosolic DNA-sensing pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 81030 | ||||||||||||||||||||||
UniGene | Hs.302123 | ||||||||||||||||||||||
RefSeq | NM_001160417 NM_001160418 NM_001160419 NM_030776 | ||||||||||||||||||||||
HUGO | HGNC:16176 | ||||||||||||||||||||||
OMIM | 606750 | ||||||||||||||||||||||
CCDS | CCDS13461 CCDS54477 CCDS54478 | ||||||||||||||||||||||
HPRD | 09484 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 81030 | ||||||||||||||||||||||