InnateDB Protein
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IDBP-82389.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZBP1
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Protein Name
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Z-DNA binding protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000360215
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InnateDB Gene
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IDBG-82385 (ZBP1)
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Protein Structure
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Function |
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000607
Double-stranded RNA-specific adenosine deaminase (DRADA)
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PFAM |
PF02295
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PRINTS |
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PIRSF |
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SMART |
SM00550
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H171
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PhosphoSite |
PhosphoSite-Q9H171
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
81030
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UniGene |
Hs.302123
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RefSeq |
NP_110403
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HUGO |
HGNC:16176
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OMIM |
606750
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CCDS |
CCDS13461
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HPRD |
09484
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IMGT |
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EMBL |
AJ300575
AK122761
AL035541
BC028218
CH471077
CT002036
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GenPept |
AAH28218
BAG53713
CAC18810
CAI23107
CAM28299
EAW75511
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