Version 5.4
Homo sapiens Gene: HHEX
Summary
InnateDB Gene IDBG-82541.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HHEX
Gene Name hematopoietically expressed homeobox
Synonyms HEX; HMPH; HOX11L-PEN; PRH; PRHX
Species Homo sapiens
Ensembl Gene ENSG00000152804
Encoded Proteins
IDBP-82543
hematopoietically expressed homeobox
IDBP-588982
hematopoietically expressed homeobox
IDBP-583444
hematopoietically expressed homeobox
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:92689951-92695646
Strand Forward strand
Band q23.33
Transcripts
ENST00000282728 ENSP00000282728
ENST00000472590 ENSP00000450017
ENST00000492654 ENSP00000447953
ENST00000551454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0008301 DNA binding, bending
GO:0017025 TBP-class protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0070491 repressing transcription factor binding
GO:0071837 HMG box domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0002009 morphogenesis of an epithelium
GO:0002573 myeloid leukocyte differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006406 mRNA export from nucleus
GO:0007165 signal transduction
GO:0007492 endoderm development
GO:0008283 cell proliferation
GO:0009611 response to wounding
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0010621 negative regulation of transcription by transcription factor localization
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016055 Wnt signaling pathway
GO:0016525 negative regulation of angiogenesis
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0022027 interkinetic nuclear migration
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030183 B cell differentiation
GO:0030878 thyroid gland development
GO:0030900 forebrain development
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016 pancreas development
GO:0034504 protein localization to nucleus
GO:0035050 embryonic heart tube development
GO:0035264 multicellular organism growth
GO:0042127 regulation of cell proliferation
GO:0043434 response to peptide hormone
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048568 embryonic organ development
GO:0048729 tissue morphogenesis
GO:0048853 forebrain morphogenesis
GO:0060431 primary lung bud formation
GO:0061009 common bile duct development
GO:0061010 gall bladder development
GO:0061011 hepatic duct development
GO:0061017 hepatoblast differentiation
GO:0070365 hepatocyte differentiation
GO:0071103 DNA conformation change
GO:0090009 primitive streak formation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024986
View Gene Order
ENSBTAG00000014217
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.118651
RefSeq NM_002729
HUGO
OMIM
CCDS CCDS7423
HPRD 06829
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca