InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HHEX

Summary

InnateDB Protein

IDBP-82543.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HHEX

Protein Name

hematopoietically expressed homeobox

Synonyms

HEX; HMPH; HOX11L-PEN; PRH; PRHX;

Species

Homo sapiens

Ensembl Protein

ENSP00000282728

InnateDB Gene

IDBG-82541 (HHEX)

Protein Structure

UniProt Annotation

Function

Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Liver and promyelocytic leukemia cell line HL- 60. {ECO:0000269PubMed:1360645, ECO:0000269PubMed:8096636, ECO:0000269PubMed:8103988}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008190	eukaryotic initiation factor 4E binding
GO:0008301	DNA binding, bending
GO:0017025	TBP-class protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0002009	morphogenesis of an epithelium
GO:0002573	myeloid leukocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006406	mRNA export from nucleus
GO:0007165	signal transduction
GO:0007492	endoderm development
GO:0008283	cell proliferation
GO:0009611	response to wounding
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0010621	negative regulation of transcription by transcription factor localization
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0016055	Wnt signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0016973	poly(A)+ mRNA export from nucleus
GO:0022027	interkinetic nuclear migration
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030183	B cell differentiation
GO:0030878	thyroid gland development
GO:0030900	forebrain development
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016	pancreas development
GO:0034504	protein localization to nucleus
GO:0035050	embryonic heart tube development
GO:0035264	multicellular organism growth
GO:0042127	regulation of cell proliferation
GO:0043434	response to peptide hormone
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048568	embryonic organ development
GO:0048729	tissue morphogenesis
GO:0048853	forebrain morphogenesis
GO:0060431	primary lung bud formation
GO:0061009	common bile duct development
GO:0061010	gall bladder development
GO:0061011	hepatic duct development
GO:0061017	hepatoblast differentiation
GO:0070365	hepatocyte differentiation
GO:0071103	DNA conformation change
GO:0090009	primitive streak formation