Version 5.4
Homo sapiens Gene: SIX6
Summary
InnateDB Gene IDBG-8257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIX6
Gene Name SIX homeobox 6
Synonyms MCOPCT2; OPTX2; Six9
Species Homo sapiens
Ensembl Gene ENSG00000184302
Encoded Proteins
IDBP-8261
SIX homeobox 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila \'sine oculis\' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:60508951-60512850
Strand Forward strand
Band q23.1
Transcripts
ENST00000327720 ENSP00000328596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007601 visual perception
GO:0009887 organ morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000021099
View Gene Order
Cross-References
SwissProt O95475
TrEMBL Q5M8S8 Q6P051
UniProt Splice Variant
Entrez Gene 4990
UniGene Hs.194756 Hs.722261
RefSeq NM_007374
HUGO HGNC:10892
OMIM 606326
CCDS CCDS9747
HPRD
IMGT
EMBL AB041399 AF031648 AF141651 AJ011785 BC065831 BC069413 BC087852
GenPept AAD49844 AAF04402 AAH65831 AAH69413 AAH87852 BAA94484 CAA09773
RNA Seq Atlas 4990

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca