Version 5.4
Mus musculus Gene: Six6
Summary
InnateDB Gene IDBG-148128.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Six6
Gene Name sine oculis-related homeobox 6
Synonyms Optx2; Six9
Species Mus musculus
Ensembl Gene ENSMUSG00000021099
Encoded Proteins
IDBP-148130
sine oculis-related homeobox 6 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184302:
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila \'sine oculis\' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:72939892-72944899
Strand Forward strand
Band C3
Transcripts
ENSMUST00000021519 ENSMUSP00000021519
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000184302
View Gene Order
Cross-References
SwissProt Q9QZ28
TrEMBL B2RSE8
UniProt Splice Variant
Entrez Gene 20476
UniGene Mm.57138
RefSeq NM_011384
OMIM
CCDS CCDS25972
HPRD
IMGT
MGI ID MGI:1341840
MGI Symbol Six6
EMBL AF050130 AF135267 AJ011787 AK017544 AK029309 BC138838 BC138839 CH466526
GenPept AAC33850 AAD48911 AAI38839 AAI38840 BAC26387 CAA09775 EDL36517
RNA Seq Atlas 20476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca