Version 5.4
Homo sapiens Gene: CAPN6
Summary
InnateDB Gene IDBG-82687.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN6
Gene Name calpain 6
Synonyms CalpM; CANPX; CAPNX; DJ914P14.1
Species Homo sapiens
Ensembl Gene ENSG00000077274
Encoded Proteins
IDBP-82689
calpain 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:111245103-111270523
Strand Reverse strand
Band q23
Transcripts
ENST00000324068 ENSP00000317214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0006508 proteolysis
GO:0051493 regulation of cytoskeleton organization
Cellular Component
GO:0005622 intracellular
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067276
View Gene Order
ENSBTAG00000000828
Not yet available
Cross-References
SwissProt Q9Y6Q1
TrEMBL F5GWQ6
UniProt Splice Variant
Entrez Gene 827
UniGene
RefSeq NM_014289
HUGO HGNC:1483
OMIM 300146
CCDS CCDS14555
HPRD 02145
IMGT
EMBL AF029232 AJ000388 AL031117 AY800242 BC000730 CH471120
GenPept AAB86605 AAH00730 AAV41896 CAA04051 CAA19965 EAX02650 EAX02651
RNA Seq Atlas 827

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca