InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPN6

Summary

InnateDB Protein

IDBP-82689.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN6

Protein Name

calpain 6

Synonyms

CalpM; CANPX; CAPNX; DJ914P14.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000317214

InnateDB Gene

IDBG-82687 (CAPN6)

Protein Structure

UniProt Annotation

Function

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:17210638}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:17210638}. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.

Disease Associations

Tissue Specificity

Expressed only in placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0006508	proteolysis
GO:0051493	regulation of cytoskeleton organization

Cellular Component

GO:0005622	intracellular
GO:0005874	microtubule
GO:0005876	spindle microtubule
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR001300 Peptidase C2, calpain, catalytic domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family

PFAM

PF00168
PF00648
PF01067

PRINTS

PR00360
PR00704

PIRSF

SMART

SM00239
SM00230
SM00720

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt