Version 5.4
Homo sapiens Gene: LGI1
Summary
InnateDB Gene IDBG-82975.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGI1
Gene Name leucine-rich, glioma inactivated 1
Synonyms ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099
Species Homo sapiens
Ensembl Gene ENSG00000108231
Encoded Proteins
IDBP-82977
leucine-rich, glioma inactivated 1
IDBP-82979
leucine-rich, glioma inactivated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:93757885-93798159
Strand Forward strand
Band q23.33
Transcripts
ENST00000371418 ENSP00000360472
ENST00000371413 ENSP00000360467
ENST00000478763
ENST00000485458
ENST00000464250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008283 cell proliferation
GO:0030307 positive regulation of cell growth
GO:0031175 neuron projection development
GO:0050806 positive regulation of synaptic transmission
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030054 cell junction
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067242
View Gene Order
ENSBTAG00000005106
Not yet available
Cross-References
SwissProt O95970
TrEMBL
UniProt Splice Variant
Entrez Gene 9211
UniGene
RefSeq NM_005097 XM_005270272
HUGO HGNC:6572
OMIM 604619
CCDS CCDS7431
HPRD 05216
IMGT
EMBL AF055636 AF473548 AK289706 AK303956 AL157396 AL358154 AY358885 BC022500 CH471066
GenPept AAC99316 AAH22500 AAM22074 AAQ89244 BAF82395 BAG64882 CAH73837 CAH73838 CAI14981 CAI14982 EAW50052
RNA Seq Atlas 9211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca