InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP2C19

Summary

InnateDB Gene

IDBG-83225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2C19

Gene Name

cytochrome P450, family 2, subfamily C, polypeptide 19

Synonyms

CPCJ; CYP2C; CYPIIC17; CYPIIC19; P450C2C; P450IIC19

Species

Homo sapiens

Ensembl Gene

ENSG00000165841

Encoded Proteins

IDBP-83227

cytochrome P450, family 2, subfamily C, polypeptide 19

IDBP-811070

IDBP-810559

cytochrome P450, family 2, subfamily C, polypeptide 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:94762624-94853260

Strand

Forward strand

Band

q23.33

Transcripts

ENST00000371321	ENSP00000360372
ENST00000464755	ENSP00000483243
ENST00000480405	ENSP00000483847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018675	(S)-limonene 6-monooxygenase activity
GO:0018676	(S)-limonene 7-monooxygenase activity
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0052741	(R)-limonene 6-monooxygenase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0046483	heterocycle metabolic process
GO:0055114	oxidation-reduction process
GO:0097267	omega-hydroxylase P450 pathway