InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2C19

Summary

InnateDB Protein

IDBP-83227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2C19

Protein Name

cytochrome P450, family 2, subfamily C, polypeptide 19

Synonyms

CPCJ; CYP2C; CYPIIC17; CYPIIC19; P450C2C; P450IIC19;

Species

Homo sapiens

Ensembl Protein

ENSP00000360372

InnateDB Gene

IDBG-83225 (CYP2C19)

Protein Structure

UniProt Annotation

Function

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018675	(S)-limonene 6-monooxygenase activity
GO:0018676	(S)-limonene 7-monooxygenase activity
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0052741	(R)-limonene 6-monooxygenase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0046483	heterocycle metabolic process
GO:0055114	oxidation-reduction process
GO:0097267	omega-hydroxylase P450 pathway