InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP2C9

Summary

InnateDB Gene

IDBG-83254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2C9

Gene Name

cytochrome P450, family 2, subfamily C, polypeptide 9

Synonyms

CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9

Species

Homo sapiens

Ensembl Gene

ENSG00000138109

Encoded Proteins

IDBP-83256

cytochrome P450, family 2, subfamily C, polypeptide 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:94938658-94989390

Strand

Forward strand

Band

q23.33

Transcripts

ENST00000260682	ENSP00000260682
ENST00000461906
ENST00000473496

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008144	drug binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018675	(S)-limonene 6-monooxygenase activity
GO:0018676	(S)-limonene 7-monooxygenase activity
GO:0020037	heme binding
GO:0034875	caffeine oxidase activity
GO:0052741	(R)-limonene 6-monooxygenase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0019627	urea metabolic process
GO:0032787	monocarboxylic acid metabolic process
GO:0042737	drug catabolic process
GO:0042738	exogenous drug catabolic process
GO:0043603	cellular amide metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0097267	omega-hydroxylase P450 pathway