InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2C9

Summary

InnateDB Protein

IDBP-83256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2C9

Protein Name

cytochrome P450, family 2, subfamily C, polypeptide 9

Synonyms

CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9;

Species

Homo sapiens

Ensembl Protein

ENSP00000260682

InnateDB Gene

IDBG-83254 (CYP2C9)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008144	drug binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018675	(S)-limonene 6-monooxygenase activity
GO:0018676	(S)-limonene 7-monooxygenase activity
GO:0020037	heme binding
GO:0034875	caffeine oxidase activity
GO:0052741	(R)-limonene 6-monooxygenase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0019627	urea metabolic process
GO:0032787	monocarboxylic acid metabolic process
GO:0042737	drug catabolic process
GO:0042738	exogenous drug catabolic process
GO:0043603	cellular amide metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0097267	omega-hydroxylase P450 pathway