Version 5.4
Homo sapiens Gene: SIX4
Summary
InnateDB Gene IDBG-8327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIX4
Gene Name SIX homeobox 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100625
Encoded Proteins
IDBP-8329
SIX homeobox 4
IDBP-597272
SIX homeobox 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:60709528-60724348
Strand Reverse strand
Band q23.1
Transcripts
ENST00000216513 ENSP00000216513
ENST00000554079
ENST00000556952 ENSP00000450761
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007519 skeletal muscle tissue development
GO:0008582 regulation of synaptic growth at neuromuscular junction
GO:0009653 anatomical structure morphogenesis
GO:0010468 regulation of gene expression
GO:0032880 regulation of protein localization
GO:0042472 inner ear morphogenesis
GO:0043524 negative regulation of neuron apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048538 thymus development
GO:0048699 generation of neurons
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048856 anatomical structure development
GO:0051451 myoblast migration
GO:0072075 metanephric mesenchyme development
GO:0072095 regulation of branch elongation involved in ureteric bud branching
GO:0072107 positive regulation of ureteric bud formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034460
View Gene Order
Cross-References
SwissProt
TrEMBL G3V2N2
UniProt Splice Variant
Entrez Gene 51804
UniGene Hs.624591 Hs.690393 Hs.708798 Hs.97849
RefSeq NM_017420 XM_005267759
HUGO HGNC:10890
OMIM 606342
CCDS CCDS9749
HPRD 06960
IMGT
EMBL AL132777
GenPept
RNA Seq Atlas 51804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca