InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP2C8

Summary

InnateDB Gene

IDBG-83291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2C8

Gene Name

cytochrome P450, family 2, subfamily C, polypeptide 8

Synonyms

CPC8; CYPIIC8; MP-12/MP-20

Species

Homo sapiens

Ensembl Gene

ENSG00000138115

Encoded Proteins

IDBP-83293

cytochrome P450, family 2, subfamily C, polypeptide 8

IDBP-585430

cytochrome P450, family 2, subfamily C, polypeptide 8

IDBP-595469

cytochrome P450, family 2, subfamily C, polypeptide 8

IDBP-594729

cytochrome P450, family 2, subfamily C, polypeptide 8

IDBP-585222

cytochrome P450, family 2, subfamily C, polypeptide 8

IDBP-592265

cytochrome P450, family 2, subfamily C, polypeptide 8

IDBP-813363

cytochrome P450, family 2, subfamily C, polypeptide 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:95036772-95069497

Strand

Reverse strand

Band

q23.33

Transcripts

ENST00000371270	ENSP00000360317
ENST00000490994	ENSP00000433314
ENST00000479946
ENST00000527420	ENSP00000433191
ENST00000526814
ENST00000527953
ENST00000533320
ENST00000525991	ENSP00000433842
ENST00000531714
ENST00000535898	ENSP00000445062
ENST00000539050	ENSP00000442343
ENST00000623108	ENSP00000485110

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0034875	caffeine oxidase activity
GO:0070330	aromatase activity

Biological Process

GO:0006082	organic acid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0097267	omega-hydroxylase P450 pathway