InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2C8

Summary

InnateDB Protein

IDBP-585222.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2C8

Protein Name

cytochrome P450, family 2, subfamily C, polypeptide 8

Synonyms

CPC8; CYPIIC8; MP-12/MP-20;

Species

Homo sapiens

Ensembl Protein

ENSP00000445062

InnateDB Gene

IDBG-83291 (CYP2C8)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). {ECO:0000269PubMed:7574697}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0034875	caffeine oxidase activity
GO:0070330	aromatase activity

Biological Process

GO:0006082	organic acid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0097267	omega-hydroxylase P450 pathway