InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SAG

Summary

InnateDB Gene

IDBG-83475.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAG

Gene Name

S-antigen; retina and pineal gland (arrestin)

Synonyms

RP47; S-AG

Species

Homo sapiens

Ensembl Gene

ENSG00000130561

Encoded Proteins

IDBP-292885

S-antigen; retina and pineal gland (arrestin)

IDBP-389371

S-antigen; retina and pineal gland (arrestin)

IDBP-389374

S-antigen; retina and pineal gland (arrestin)

IDBP-389375

S-antigen; retina and pineal gland (arrestin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:233307816-233347055

Strand

Forward strand

Band

q37.1

Transcripts

ENST00000409110	ENSP00000386444
ENST00000447536	ENSP00000408937
ENST00000415974	ENSP00000409475
ENST00000453143	ENSP00000404733
ENST00000412969
ENST00000476500
ENST00000462487
ENST00000471884
ENST00000479450
ENST00000474206
ENST00000461532
ENST00000469222
ENST00000483231
ENST00000473771
ENST00000474220
ENST00000492629

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002046	opsin binding
GO:0004864	protein phosphatase inhibitor activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000056055

View Gene Order

ENSBTAG00000021480

Not yet available

Pathways

NETPATH

REACTOME

REACT_163932

Activation of the phototransduction cascade pathway

REACT_111102

Signal Transduction pathway

REACT_160102

Diseases associated with visual transduction pathway

REACT_160125

Visual phototransduction pathway

REACT_163722

The phototransduction cascade pathway

REACT_163919

Inactivation, recovery and regulation of the phototransduction cascade pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

rhodopsin_pathway

Visual signal transduction: Rods

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.32721

RefSeq

NM_000541 XM_005246099

HUGO

OMIM

CCDS

CCDS46545

HPRD

01625

IMGT

EMBL

GenPept

RNA Seq Atlas