Version 5.4
Homo sapiens Gene: USP40
Summary
InnateDB Gene IDBG-83522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP40
Gene Name ubiquitin specific peptidase 40
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000085982
Encoded Proteins
IDBP-83524
ubiquitin specific peptidase 40
IDBP-292884
ubiquitin specific peptidase 40
IDBP-389384
ubiquitin specific peptidase 40
IDBP-389385
ubiquitin specific peptidase 40
IDBP-389386
ubiquitin specific peptidase 40
IDBP-389387
ubiquitin specific peptidase 40
IDBP-389392
ubiquitin specific peptidase 40
IDBP-389393
ubiquitin specific peptidase 40
IDBP-389396
ubiquitin specific peptidase 40
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:233475520-233566782
Strand Reverse strand
Band q37.1
Transcripts
ENST00000251722 ENSP00000251722
ENST00000409945 ENSP00000386664
ENST00000450966 ENSP00000415434
ENST00000450940 ENSP00000407696
ENST00000454354 ENSP00000394133
ENST00000430158 ENSP00000388121
ENST00000427112 ENSP00000387898
ENST00000452724 ENSP00000408853
ENST00000427947
ENST00000443711 ENSP00000394154
ENST00000483519
ENST00000464956
ENST00000496298
ENST00000473191
ENST00000483216
ENST00000485943
ENST00000484528
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005501
View Gene Order
ENSBTAG00000000149
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614315 Hs.637897 Hs.96513
RefSeq NM_018218 XM_005246088 XM_005246091 XM_006712612
HUGO
OMIM
CCDS CCDS46547
HPRD 07166
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca