InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF11

Summary

InnateDB Gene

IDBG-83752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF11

Gene Name

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa

Synonyms

MGC:15243; TAF2I; TAFII28

Species

Homo sapiens

Ensembl Gene

ENSG00000064995

Encoded Proteins

IDBP-83754

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa

IDBP-376178

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:34877778-34888089

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000361288	ENSP00000354633
ENST00000420584	ENSP00000408121

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	36 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042809	vitamin D receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046966	thyroid hormone receptor binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0043923	positive regulation by host of viral transcription