Version 5.4
Homo sapiens Gene: AGAP1
Summary
InnateDB Gene IDBG-84008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGAP1
Gene Name ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157985
Encoded Proteins
IDBP-84010
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-84012
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-292874
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-292875
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-292877
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-387381
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-389437
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-389438
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-809516
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
IDBP-809520
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:235494089-236131800
Strand Forward strand
Band q37.2
Transcripts
ENST00000304032 ENSP00000307634
ENST00000336665 ENSP00000338378
ENST00000409457 ENSP00000387174
ENST00000402604 ENSP00000385492
ENST00000409538 ENSP00000386897
ENST00000428334 ENSP00000411824
ENST00000448025 ENSP00000403482
ENST00000418654 ENSP00000393838
ENST00000453371
ENST00000466575
ENST00000482882
ENST00000614409 ENSP00000484463
ENST00000619456 ENSP00000483085
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005543 phospholipid binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055013
View Gene Order
ENSBTAG00000016504
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q4ZG22 Q53RW1 Q53S93
UniProt Splice Variant
Entrez Gene 116987
UniGene
RefSeq NM_001037131 NM_001244888 NM_014914 XM_005246058 XM_005246059 XM_006712241
HUGO HGNC:16922
OMIM 608651
CCDS CCDS2514 CCDS33408 CCDS58756
HPRD
IMGT
EMBL AC019047 AC064874 AC079400
GenPept AAX88852 AAY14697 AAY24137
RNA Seq Atlas 116987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca