Version 5.4
Homo sapiens Protein: AGAP1
Summary
InnateDB Protein IDBP-292874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGAP1
Protein Name ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387174
InnateDB Gene IDBG-84008 (AGAP1)
Protein Structure
UniProt Annotation
Function GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269PubMed:12640130}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12388557, ECO:0000269PubMed:12640130}. Note=Associates with the endocytic compartment.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12388557, ECO:0000269PubMed:12640130, ECO:0000269PubMed:15381706, ECO:0000269PubMed:16079295}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
GO:0005543 phospholipid binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00071
PF08477
PRINTS PR00449
PIRSF
SMART SM00175
SM00173
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPQ3
PhosphoSite PhosphoSite-Q9UPQ3
TrEMBL Q53S93
UniProt Splice Variant
Entrez Gene 116987
UniGene Hs.606473
RefSeq NP_001231817
HUGO HGNC:16922
OMIM 608651
CCDS CCDS58756
HPRD 16359
IMGT
EMBL AB029022 AC012305 AC019047 AC064874 AC073989 AC079400 AF413078 AK001722 AY033765 BC060814 BC140856
GenPept AAH60814 AAI40857 AAK56506 AAL04172 AAX88857 AAY24137 BAA83051 BAA91862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca