Version 5.4
Homo sapiens Gene: COPS8
Summary
InnateDB Gene IDBG-84173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS8
Gene Name COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
Synonyms COP9; CSN8; SGN8
Species Homo sapiens
Ensembl Gene ENSG00000198612
Encoded Proteins
IDBP-84175
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
IDBP-246536
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
IDBP-292867
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
IDBP-389457
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
IDBP-389458
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20074051
COPS8 is part of the COP9 signallosome that functions to control NF-kappaB activation.
Entrez Gene
Summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:237085312-237100466
Strand Forward strand
Band q37.3
Transcripts
ENST00000354371 ENSP00000346340
ENST00000392008 ENSP00000375865
ENST00000409334 ENSP00000387212
ENST00000419015 ENSP00000388655
ENST00000447464 ENSP00000413696
ENST00000470452
ENST00000465362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 68 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008285 negative regulation of cell proliferation
GO:0010388 cullin deneddylation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034432
View Gene Order
ENSBTAG00000005854
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.669956 Hs.698104
RefSeq NM_006710 NM_198189
HUGO
OMIM
CCDS CCDS2517 CCDS42835
HPRD 16737
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca