Version 5.4
Homo sapiens Protein: COPS8
Summary
InnateDB Protein IDBP-84175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS8
Protein Name COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
Synonyms COP9; CSN8; SGN8;
Species Homo sapiens
Ensembl Protein ENSP00000346340
InnateDB Gene IDBG-84173 (COPS8)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:9535219}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9535219}. Nucleus {ECO:0000269PubMed:9535219}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 68 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008285 negative regulation of cell proliferation
GO:0010388 cullin deneddylation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99627
PhosphoSite PhosphoSite-Q99627
TrEMBL B8ZZP3
UniProt Splice Variant
Entrez Gene 10920
UniGene Hs.698104
RefSeq NP_006701
HUGO HGNC:24335
OMIM
CCDS CCDS2517
HPRD 16737
IMGT
EMBL AC105760 AK289891 BC003090 BC036499 BC080617 CH471063 CR456994 U51205
GenPept AAB38529 AAH03090 AAH36499 AAH80617 AAY14978 BAF82580 CAG33275 EAW71097 EAW71098 EAW71099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca