InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HRH3

Summary

InnateDB Gene

IDBG-84247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRH3

Gene Name

histamine receptor H3

Synonyms

GPCR97; HH3R

Species

Homo sapiens

Ensembl Gene

ENSG00000101180

Encoded Proteins

IDBP-84249

histamine receptor H3

IDBP-84251

histamine receptor H3

IDBP-808651

histamine receptor H3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:62214970-62220267

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000340177	ENSP00000342560
ENST00000317393	ENSP00000321482
ENST00000611492	ENSP00000482567

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity
GO:0008144	drug binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007269	neurotransmitter secretion
GO:0007420	brain development
GO:0007612	learning
GO:0007613	memory
GO:0014050	negative regulation of glutamate secretion
GO:0014053	negative regulation of gamma-aminobutyric acid secretion
GO:0014061	regulation of norepinephrine secretion
GO:0014063	negative regulation of serotonin secretion
GO:0014070	response to organic cyclic compound
GO:0042755	eating behavior
GO:0042756	drinking behavior
GO:0045776	negative regulation of blood pressure
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050890	cognition

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043209	myelin sheath

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039059

View Gene Order

ENSBTAG00000031625

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_16903

Histamine receptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

Q9Y5N1

TrEMBL

Q8NCH4

UniProt Splice Variant

Entrez Gene

11255

UniGene

Hs.251399

RefSeq

NM_007232

HUGO

HGNC:5184

OMIM

604525

CCDS

CCDS13493

HPRD

IMGT

EMBL

AB019000 AB045369 AF140538 AF363791 AJ278250 AJ296652 AK074730 AL078633 BC096840

GenPept

AAD38151 AAH96840 AAK50040 BAB17030 BAB20090 BAC11167 CAC04014 CAC39434 CAC51025

RNA Seq Atlas

11255