Version 5.4
Homo sapiens Gene: HES6
Summary
InnateDB Gene IDBG-84508.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HES6
Gene Name hairy and enhancer of split 6 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144485
Encoded Proteins
IDBP-84510
hairy and enhancer of split 6 (Drosophila)
IDBP-292844
hairy and enhancer of split 6 (Drosophila)
IDBP-292846
hairy and enhancer of split 6 (Drosophila)
IDBP-292847
hairy and enhancer of split 6 (Drosophila)
IDBP-292861
hairy and enhancer of split 6 (Drosophila)
IDBP-292855
hairy and enhancer of split 6 (Drosophila)
IDBP-389536
hairy and enhancer of split 6 (Drosophila)
IDBP-389537
hairy and enhancer of split 6 (Drosophila)
IDBP-389538
hairy and enhancer of split 6 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:238238267-238240662
Strand Reverse strand
Band q37.3
Transcripts
ENST00000272937 ENSP00000272937
ENST00000409002 ENSP00000387155
ENST00000409182 ENSP00000387343
ENST00000409160 ENSP00000387215
ENST00000409574 ENSP00000387008
ENST00000409356 ENSP00000387107
ENST00000417803 ENSP00000401797
ENST00000436051 ENSP00000392596
ENST00000450098 ENSP00000390870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0008134 transcription factor binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067071
View Gene Order
ENSBTAG00000009870
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
INOH
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001142853 NM_001282434 NM_018645
HUGO
OMIM
CCDS CCDS2527 CCDS46556 CCDS63180
HPRD 11021
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca