InnateDB Protein
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IDBP-292844.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HES6
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Protein Name
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hairy and enhancer of split 6 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000387155
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InnateDB Gene
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IDBG-84508 (HES6)
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Protein Structure
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Function |
Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003650
Orange
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF07527
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q96HZ4
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PhosphoSite |
PhosphoSite-Q96HZ4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55502
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UniGene |
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RefSeq |
NP_001136325
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HUGO |
HGNC:18254
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OMIM |
610331
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CCDS |
CCDS46556
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HPRD |
11021
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IMGT |
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EMBL |
AB035179
AC016757
AF260237
AK075040
AK293111
BC007939
CH471063
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GenPept |
AAH07939
AAK51634
AAY24337
BAA96082
BAC11368
BAF85800
EAW71151
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