Version 5.4
Homo sapiens Gene: ASB1
Summary
InnateDB Gene IDBG-84556.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB1
Gene Name ankyrin repeat and SOCS box containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000065802
Encoded Proteins
IDBP-84558
ankyrin repeat and SOCS box containing 1
IDBP-292854
ankyrin repeat and SOCS box containing 1
IDBP-389544
ankyrin repeat and SOCS box containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:238426742-238452250
Strand Forward strand
Band q37.3
Transcripts
ENST00000264607 ENSP00000264607
ENST00000409297 ENSP00000387025
ENST00000438264 ENSP00000411773
ENST00000463352
ENST00000469885
ENST00000491653
ENST00000468122
ENST00000481566
ENST00000473306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030539 male genitalia development
GO:0035556 intracellular signal transduction
GO:0042036 negative regulation of cytokine biosynthetic process
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026311
View Gene Order
ENSBTAG00000003376
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516788 Hs.613565 Hs.617770
RefSeq NM_001040445 XM_005246080
HUGO
OMIM
CCDS CCDS33416
HPRD 05767
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca