Version 5.4
Homo sapiens Gene: SCAI
Summary
InnateDB Gene IDBG-85053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCAI
Gene Name suppressor of cancer cell invasion
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173611
Encoded Proteins
IDBP-85055
suppressor of cancer cell invasion
IDBP-85057
suppressor of cancer cell invasion
IDBP-483727
suppressor of cancer cell invasion
IDBP-477535
suppressor of cancer cell invasion
IDBP-478045
suppressor of cancer cell invasion
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:124942608-125143506
Strand Reverse strand
Band q33.3
Transcripts
ENST00000336505 ENSP00000336756
ENST00000373549 ENSP00000362650
ENST00000477186 ENSP00000419576
ENST00000467917 ENSP00000418148
ENST00000494102 ENSP00000419358
ENST00000487795
ENST00000468569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030336 negative regulation of cell migration
GO:0035024 negative regulation of Rho protein signal transduction
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035236
View Gene Order
ENSBTAG00000015553
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.59504
RefSeq NM_001144877 NM_173690
HUGO
OMIM
CCDS CCDS43877 CCDS48017
HPRD 12941
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca