Version 5.4
Homo sapiens Protein: SCAI
Summary
InnateDB Protein IDBP-85055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCAI
Protein Name suppressor of cancer cell invasion
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000336756
InnateDB Gene IDBG-85053 (SCAI)
Protein Structure
UniProt Annotation
Function Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269PubMed:19350017}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269PubMed:19350017}. Cytoplasm {ECO:0000269PubMed:19350017}. Note=Nuclear localization is required for inhibition of MKL1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030336 negative regulation of cell migration
GO:0035024 negative regulation of Rho protein signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR016607 Protein SCAI, metazoan/viridiplantae
IPR022709 Protein SCAI
PFAM PF12070
PRINTS
PIRSF PIRSF013022
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N9R8
PhosphoSite PhosphoSite-Q8N9R8
TrEMBL
UniProt Splice Variant
Entrez Gene 286205
UniGene Hs.59504
RefSeq NP_001138349
HUGO HGNC:26709
OMIM
CCDS CCDS48017
HPRD 12941
IMGT
EMBL AK098024 AL445930 AL451125 BC104030 BC104031 CH471090
GenPept AAI04031 AAI04032 BAC05217 CAI13674 CAI14348 EAW87608 EAW87609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca