InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGD2

Summary

InnateDB Gene

IDBG-85423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGD2

Gene Name

FYVE, RhoGEF and PH domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000146192

Encoded Proteins

IDBP-85425

FYVE, RhoGEF and PH domain containing 2

IDBP-85429

FYVE, RhoGEF and PH domain containing 2

IDBP-477150

FYVE, RhoGEF and PH domain containing 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:37005646-37029070

Strand

Forward strand

Band

p21.2

Transcripts

ENST00000373535	ENSP00000362635
ENST00000274963	ENSP00000274963
ENST00000489356
ENST00000497659	ENSP00000419657
ENST00000459781
ENST00000487975
ENST00000464083
ENST00000494343
ENST00000470273
ENST00000493635
ENST00000487920

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0030027	lamellipodium
GO:0031901	early endosome membrane
GO:0032587	ruffle membrane