Version 5.4
Mus musculus Gene: Fgd2
Summary
InnateDB Gene IDBG-160622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgd2
Gene Name FYVE, RhoGEF and PH domain containing 2
Synonyms Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4
Species Mus musculus
Ensembl Gene ENSMUSG00000024013
Encoded Proteins
IDBP-160624
FYVE, RhoGEF and PH domain containing 2
IDBP-540870
FYVE, RhoGEF and PH domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146192:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:29360914-29379660
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000024810 ENSMUSP00000024810
ENSMUST00000123989 ENSMUSP00000118828
ENSMUST00000145124
ENSMUST00000146800
ENSMUST00000138537
ENSMUST00000137644
ENSMUST00000140918
ENSMUST00000144616
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
Biological Process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0031901 early endosome membrane
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000146192
View Gene Order
ENSBTAG00000014172
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_210090
Rho GTPase cycle pathway
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.279187
RefSeq NM_001159538 NM_013710 XM_006524301 XM_006524302 XM_006524303
OMIM
CCDS CCDS37537
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca