Version 5.4
Homo sapiens Gene: ANKRD2
Summary
InnateDB Gene IDBG-85517.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKRD2
Gene Name ankyrin repeat domain 2 (stretch responsive muscle)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165887
Encoded Proteins
IDBP-85519
ankyrin repeat domain 2 (stretch responsive muscle)
IDBP-85521
ankyrin repeat domain 2 (stretch responsive muscle)
IDBP-85523
ankyrin repeat domain 2 (stretch responsive muscle)
IDBP-384006
ankyrin repeat domain 2 (stretch responsive muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response to physiologic stress, injury, and hypertrophy (Miller et al., 2003 [PubMed 14583192]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:97572499-97583884
Strand Forward strand
Band q24.2
Transcripts
ENST00000307518 ENSP00000306163
ENST00000298808 ENSP00000298808
ENST00000370655 ENSP00000359689
ENST00000455090 ENSP00000403114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0031432 titin binding
GO:0043422 protein kinase B binding
Biological Process
GO:0006936 muscle contraction
GO:0007517 muscle organ development
GO:0035914 skeletal muscle cell differentiation
GO:0045662 negative regulation of myoblast differentiation
Cellular Component
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016605 PML body
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0031674 I band
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025172
View Gene Order
ENSBTAG00000012720
Not yet available
Cross-References
SwissProt Q9GZV1
TrEMBL Q5T457
UniProt Splice Variant
Entrez Gene 26287
UniGene Hs.73708
RefSeq NM_001129981 NM_001291219 NM_001291218 NM_020349
HUGO HGNC:495
OMIM 610734
CCDS CCDS44468 CCDS7466
HPRD 12460
IMGT
EMBL AB058599 AJ249975 AJ304804 AJ304805 AJ583444 AK056990 AL355315 AL359388 BC020817 BC107759
GenPept AAH20817 AAI07760 BAB60958 CAB99416 CAC19411 CAC19412 CAE47432
RNA Seq Atlas 26287

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca