Version 5.4
Homo sapiens Protein: ANKRD2
Summary
InnateDB Protein IDBP-85521.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKRD2
Protein Name ankyrin repeat domain 2 (stretch responsive muscle)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298808
InnateDB Gene IDBG-85517 (ANKRD2)
Protein Structure
UniProt Annotation
Function Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269PubMed:21737686, ECO:0000269PubMed:22016770}.
Subcellular Localization Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
Disease Associations
Tissue Specificity Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level). {ECO:0000269PubMed:11444853, ECO:0000269PubMed:11453652}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0043422 protein kinase B binding
Biological Process
GO:0006936 muscle contraction
GO:0007517 muscle organ development
GO:0045662 negative regulation of myoblast differentiation
Cellular Component
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016605 PML body
GO:0031674 I band
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZV1
PhosphoSite PhosphoSite-Q9GZV1
TrEMBL Q5T457
UniProt Splice Variant
Entrez Gene 26287
UniGene Hs.73708
RefSeq NP_001278148
HUGO HGNC:495
OMIM 610734
CCDS CCDS44468
HPRD 12460
IMGT
EMBL AB058599 AJ249975 AJ304804 AJ304805 AJ583444 AK056990 AL355315 AL359388 BC020817 BC107759
GenPept AAH20817 AAI07760 BAB60958 CAB99416 CAC19411 CAC19412 CAE47432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca